List of one- and two-digit interstate highways in the United States:
| Interstate 4 | Florida | |
| Interstate 5 | Washington, Oregon, California | |
| Interstate 8 | Arizona, California | |
| Interstate 10 | Florida, Alabama, Mississippi, Louisiana, Texas, New Mexico, Arizona, California | |
| Interstate 12 | Louisiana | |
| Interstate 15 | Montana, Idaho, Utah, Arizona, Nevada, California | |
| Interstate 16 | Georgia | |
| Interstate 17 | Arizona | |
| Interstate 19 | Arizona | |
| Interstate 20 | South Carolina, Georgia, Alabama, Mississippi, Louisiana, Texas | |
| Interstate 24 | Tennessee, Georgia, Tennessee (again), Kentucky, Illinois | |
| Interstate 25 | Wyoming, Colorado, New Mexico | |
| Interstate 26 | South Carolina, North Carolina, Tennessee | |
| Interstate 27 | Texas | |
| Interstate 29 | North Dakota, South Dakota, Iowa, Missouri | |
| Interstate 30 | Arkansas, Texas | |
| Interstate 35 | Minnesota, Iowa, Missouri, Kansas, Oklahoma, Texas | |
| Interstate 37 | Texas | |
| Interstate 39 | Wisconsin, Illinois | |
| Interstate 40 | North Carolina, Tennessee, Arkansas, Oklahoma, Texas, New Mexico, Arizona, California | |
| Interstate 43 | Wisconsin | |
| Interstate 44 | Missouri, Oklahoma, Texas | |
| Interstate 45 | Texas | |
| Interstate 49 | Louisiana | |
| Interstate 55 | Illinois, Missouri, Arkansas, Tennessee, Mississippi, Louisiana | |
| Interstate 57 | Illinois, Missouri | |
| Interstate 59 | Georgia, Alabama, Mississippi, Louisiana | |
| Interstate 64 | Virginia, West Virginia, Kentucky, Indiana, Illinois, Missouri | |
| Interstate 65 | Indiana, Kentucky, Tennessee, Alabama | |
| Interstate 66 | District of Columbia, Virginia | |
| Interstate 68 | Maryland, West Virginia | |
| Interstate 69 | Michigan, Indiana | |
| Interstate 70 | Maryland, Pennsylvania, West Virginia, Ohio, Indiana, Illinois, Missouri, Kansas, Colorado, Utah | |
| Interstate 71 | Ohio, Kentucky | |
| Interstate 72 | Illinois, Missouri | |
| Interstate 73 | North Carolina | |
| Interstate 74 | Ohio, Indiana, Illinois, Iowa | |
| Interstate 75 | Michigan, Ohio, Kentucky, Tennessee, Georgia, Florida (See Also: Alligator Alley) | |
| Interstate 76 | Eastern: New Jersey, Pennsylvania, Ohio; Western: Nebraska, Colorado | |
| Interstate 77 | Ohio, West Virginia, Virginia, North Carolina, South Carolina | |
| Interstate 78 | New York, New Jersey, Pennsylvania | |
| Interstate 79 | Pennsylvania, West Virginia | |
| Interstate 80 | New Jersey, Pennsylvania, Ohio, Indiana, Illinois, Iowa, Nebraska, Wyoming, Utah, Nevada, California | |
| Interstate 81 | New York, Pennsylvania, Maryland, West Virginia, Virginia, Tennessee | |
| Interstate 82 | Oregon, Washington | |
| Interstate 83 | Pennsylvania, Maryland | |
| Interstate 84 | Eastern: Massachusetts, Connecticut, New York, Pennsylvania; Western: Utah, Idaho, Oregon | |
| Interstate 85 | Virginia, North Carolina, South Carolina, Georgia, Alabama | |
| Interstate 86 | Eastern: New York, Pennsylvania; Western: Idaho | |
| Interstate 87 | New York | |
| Interstate 88 | Eastern: New York; Western: Illinois | |
| Interstate 89 | Vermont, New Hampshire | |
| Interstate 90 | Massachusetts, New York, Pennsylvania, Ohio, Indiana, Illinois, Wisconsin, Minnesota, South Dakota, Wyoming, Montana, Idaho, Washington | |
| Interstate 91 | Vermont, Connecticut, Massachusetts | |
| Interstate 93 | Vermont, New Hampshire, Massachusetts | |
| Interstate 94 | Michigan, Indiana, Illinois, Wisconsin, Minnesota, North Dakota, Montana | |
| Interstate 95 | Maine, New Hampshire, Massachusetts, Rhode Island, Connecticut, New York, New Jersey, Pennsylvania, Delaware, Maryland, Virginia, North Carolina, South Carolina, Georgia, Florida | |
| Interstate 96 | Michigan | |
| Interstate 97 | Maryland | |
| Interstate 99 | Pennsylvania | |
| Interstate 238 | California (an unusual exception to the rules) |
Hawaii interstates include:
Note: Three-digit interstates (with the exception of I-238) are to be discussed in the same article as the one- or two-digit interstate that the three-digit interstate is a spur or loop of, even if plans to build the connection between the "spur" and the main highway never materialized. For example, I-170 is discussed in the I-70 article, and I-278 in New York and New Jersey is discussed in the I-78 article, even though no connection exists between I-78 and any of its spurs or loops. I-238 is an exception because it is not a loop or spur of any one- or two-digit interstate (no I-38 exists anywhere near I-238).