In 1905, before the establishment of the Republic of China, he met Sun Yat-sen in Europe, then he joined the Tong Meng Hui. He also became the first Academic Scholar of the Humanity Division (人文組院士) of the Academia Sinica (中央研究院), and a representative in the National People's Delegate Conferences (國民大會). He immigrated to Taiwan and was the teacher of Chiang Ching-kuo. He died in Taipei at the age of 88.
He was also respected for his various styles of calligraphy, which is evident in the design of chu-yin, all of its symbols have the strokes and essence of calligraphy.
His publications can be found in The Collection of the Works of Mr. Wu Chih-hui (《吳稚暉先生集》).