One of Myers' first acting jobs was with SNL star Gilda Radner in a TV commercial when he was nine years old. Myers graduated from High School in 1982 and was immediately accepted into Toronto's Second City Comedy troupe.
Myers became well-known as a member of the cast of NBC's Saturday Night Live television program from 1989 to 1995, where he performed characters like "Dieter", "Linda Richman" and "Wayne Cambell", from Wayne's World.
In 54, Myers played his first movie non-comedic role as the proprietor of Studio 54, a famous New York discotheque of the 1970's. The film was moderately successful; Myers' performance was widely praised.
In June of 2000, Myers was sued by Universal Pictures for $3.8 million for backing out of a contract to play "Dieter", the SNL character, in a feature film. Myers said he refused to honor the 20 million dollar contract because he didn't want to cheat moviegoers with an unacceptable script. Myers countersued, and a settlement was reached after several months where Myers agreed to make another film with Universal.
In November, 2003, Myers starred as The Cat in the Hat in the movie of the same name.