In the early 1980s, Microprose was primarily known as a publisher of flight and military simulation titles for 8-bit home computers such as the Commodore 64, Apple II, and Atari 8-bit family. As the industry changed, it moved with it, supporting IBM PC compatibles and 68000-based machines like the Amiga and Atari ST. Also in the mid- to late-1980s, Microprose began publishing a number of strategy games.
In 1990 and 1991 it released the blockbusters Railroad Tycoon and Civilization, which quickly became two of the best-selling strategy games of all time. However, the company quickly ran into financial trouble because it followed those releases with a large number of titles into a saturated market. It also made an unsuccessful venture into the creation of an arcade flight simulator.
In 1993, Microprose was acquired by Spectrum Holobyte. Both brand names continued until 1996, when the combined company consolidated all of its titles under the Microprose brand. Sid Meier departed the company after the buyout, forming a new company called Firaxis Games.
In 1999, Hasbro Interactive closed the former Microprose studios in California and North Carolina. In 2001, after French game publisher Infogrames (now Atari) took over Hasbro Interactive, the label ceased to exist entirely, with remaining titles in its catalog being relabeled and re-released.