Guy came to the throne on the death of his cousin Leo V of Armenia. The crown had first been offered to his younger brother John of Lusignan who urged Guy to accept the crown. Guy was reluctant; his mother and two of his brothers had been murdered by Oshin of Corycos during Oshin's term as regent, Oshin turn had been murdered at the behest of Leo V, and (in turn) Leo V had been murdered by the barons.
Guy was killed in an uprising in 1344 and was succeeded by a distant cousin, Constantine V.
He was married twice. He had two children by his second wife Theodora Syrgianes.
| Preceded by: Leo V | Kingdom of Armenia | Followed by: Constantine V |
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