After serving just two terms in the United States House of Representatives, Bryan reached the pinnacle of his political career. In 1896, Bryan defeated incumbent president Grover Cleveland to win the Democratic party nomination for president. Just thirty-six, Bryan managed to attract the support of mainstream Democrats as well as disaffected third party Populists and Free Silverites. His moving Cross of gold speech, delivered prior to his nomination, lambasted Eastern monied classes for supporting the gold standard at the expense of the average worker. Bryan's stance, directly opposing conservative Grover Cleveland, united splintered Democrats and won the handsome "Boy Orator of the Platte" the nomination.
Bryan logged more than 18,000 miles while visiting 27 states in the campaign of 1896. The unpopularity of the incumbent party combined with the Republican candidate's well-filled war chest, catapulted William McKinley into the White House, by a margin of 271 to 176 in the electoral college. Still, Bryan's following was large enough to result in two additional runs for president. Bryan lost again to McKinley in 1900 and to William Howard Taft in 1908.
Although he never won an election after 1892, Bryan wielded considerable influence. After helping Woodrow Wilson secure the Democratic nomination in 1912, he served as secretary of state. A committed pacifist, Bryan resigned his position as the nation approached World War I.
Although he moved to a large home in Florida, Bryan never retired. Always pious, during the final years of his life he was extremely active in religious organizations. By the 1920s, Bryan was among America's most outspoken critics of the theory of evolution. Echoing his earlier support of Prohibition, Bryan actively supported a constitutional amendment banning schools from teaching evolution. His participation in the famous 1925 Scopes Trial served as a capstone to his career. Bryan was exhausted by the trial, especially his examination at the hands of Clarence Darrow who, in an unusual move, called Bryan to the stand. Although Bryan prevailed at the trial, he died just five days after its conclusion on July 26, 1925.