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In anatomy, the stomach is an organ in the alimentary canal used to store and digest food. Generally, the stomach's primary function is not the adsorption of nutrients from digested food; this task is usually performed by the intestine. Latin names for the stomach include Ventriculus and Gaster; many medical terms related to the stomach start in "gastro-" or "gastric".

The location of the stomach in the body.

In humans, the stomach is a highly acidic environment (maintained by the secretion of hydrochloric acid) with peptidase digestive enzymes.

In ruminants, the stomach is a large multichambered organ that hosts symbiotic bacteria which produce enzymes required for the digestion of cellulose from plant matter. The partially digested plant matter passes through each of the stomach's chambers in sequence, being regurgitated and rechewed at least once in the process.

Table of contents
1 Anatomy of the human stomach
2 Histology of the human stomach
3 Control of secretion and motility

Anatomy of the human stomach

Diagram of the stomach, showing the different regions.
The stomach lies between the
esophagus and the first part of the small intestine (the duodenum). It is on the right side of the abdominal cavity, the fundus of the stomach lying against the diaphragm. Lying beneath the stomach is the pancreas, and the greater omentum hangs from the greater curvature.

It is divided into five sections, each of which have different cells and functions...

Histology of the human stomach

Like the other parts of the gastrointestinal system, the stomach walls are made of a number of layers.

Starting inside the stomach (the lumen) going out, the first main layer is the mucosa. This consists of an epithelium, the lamina propria underneath, and a thin bit of smooth muscle called the muscularis mucosa.

The submucosa lies under this and consists of fibrous connective tissue, it separates the mucosa from the next layer, the muscularis externa. The muscularis in the stomach differs from other GI organs in that it has three layers of muscle instead of two. Under these muscle layers is the adventitia, layers of connective tissue continuous with the omenta.

The epithelium of the stomach forms deep pits...

Different types of cells are at different locations down the pits. The cells at the base of these pits are chief cells, responsible for production of pepsinogen, a precursor for an enzyme that degrades protein.

Further up the pits, parietal cells produce hydrochloric acid (HCl), necessary for the digestion of food, and also the activation of pepsinogen, turning it into pepsin.

Near the top of the pits, closest to the contents of the stomach, there are mucus producing cells that help protect the stomach from self-digestion.

The muscularis externa, as previously mentioned, is made up of three layers of smooth muscle. The innermost layer is obliquely orientated, this is not seen in other parts of the digestive system, this layer is responsible for creating the motion that churns and physically breaks down the food. The next muscle layers are the circular and then the longituditinal, which are present as in other parts of the GI tract.

Control of secretion and motility

The movement and the flow of chemicals into the stomach are controlled by both the autonomic nervous system and by various digestive system hormones.

The hormone gastrin causes increased secretion of HCl, pepsinogen and intrinsic factor from parietal cells in the stomach. It also causes increased motility in the stomach. Gastrin is released by G cells in the stomach to distenstion of the antrum, and digestive products. It is inhibited by a low pH (high acid), as well as the hormone somatostatin.

Cholecystokinin (CCK) has most effect on the gall bladder, but it also decreases gastric emptying. Similarly secretin, produced in the small intestine, has most effects on the pancreas, but will also diminish acid secretion in the stomach.

Gastric inhibitory peptide (GIP) and enteroglucagon decrease both gastric acid and motility.

Other than gastrin, these hormones all act to turn off the stomach action. This is in response to food products in the intestines, which have not yet been absorbed. The stomach only needs to push food into the small intestine when the intestine isn't busy. While the intestine is full and still digesting food, the stomach acts as a storage hopper for food.

This pattern is also present in the nervous control of the stomach...

See also: cardia, stomach cancer, peptic ulcer, stomach ache, nasogastric tube