The Wye is largely unpolluted and is therefore considered one of the best rivers for salmon fishing in Britain, outside of Scotland. It is also a popular river with canoeists due to the relatively slow flowing water, making it good for beginners and the rapids at Symonds Yat which are slightly more challenging. Walkers can enjoy the Wye Valley Walk which follows the route of the River Wye from Hay-on-Wye to Chepstow along a series of well maintained way-marked paths.
The lower 16 miles of the river from Redbrook to Chepstow forms the border between England and Wales. A viewpoint near The Biblins on the Wye is known as 'Three counties view' as it is the meeting place of the counties of Herefordshire, Gloucestershire and Monmouthshire.