For example, in a 2- or 3-dimensional Euclidean space, two vectors are orthogonal if their dot product is zero, i.e., they make an angle of 90 degrees or ^{π}/_{2} radians. Hence orthogonality is a generalization of the concept of perpendicular.

Several vectors are called *pairwise orthogonal* if any two of them are orthogonal, and a set of such vectors is called an *orthogonal set*. They are said to be *orthonormal* if they are all unit vectors. Non-zero pairwise orthogonal vectors are always linearly independent.

Functions may also be **orthogonal** with respect to some nonnegative *weight function* in the sense that their inner products are

See also orthogonal matrix.

Other meanings of the word *orthogonal* evolved from its earlier use in mathematics.

In computer science, an instruction set is said to be

Orthogonality is a system design property which enables the making of complex designs feasible and compact. The aim of an orthogonal design is to achieve that operations within one of its components do not create nor propagate side-effects to other components. For example a car has orthogonal components and controls, e.g. accelerating the vehicle does not influence anything else but the components involved in the acceleration. It would be a non orthogonal design were for example the acceleration to influence the radio tunning, or the display of time.

Orthogonality achieves that modifying the technical effect produced by a component of a system does not create or propagate side effects to other components of the system. The emergent behaviour of a system consisting of components should be controlled strictly by formal definitions of its logic and not by side effects resulting from poor integration, i.e. non-orthogonal design of modules and interfaces. Orthogonality reduces the test and development time, because it's easier to verify designs that that neither cause side effects nor depend on them.

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In radio communications, multiple access schemes are **orthogonal** when a receiver can (theoretically) completely reject an arbitrarily strong unwanted signal. The orthogonal schemes are TDMA and FDMA. A non-orthogonal scheme is Code Division Multiple Access, CDMA.