Foray was born in Springfield, Massachusetts, where her voice was first broadcast in a local radio drama when she was 12 years of age; by age of 15 she was doing regular radio voice work. Two years later she moved to Los Angeles, California, and soon became a popular voice actress on radio there, including on the national programs of Jimmy Durante and Danny Thomas. In the 1940s she began film work as well, including a few apperances acting in live action movies, but mostly doing voice overs for animated cartoons.
For Walt Disney, she played "Lucifer the Cat" in the feature film Cinderella; she did a variety of voices in Walter Lantz's Woody Woodpecker cartoons; for Warner Brothers she was Granny, owner of Tweety and Sylvester, and, memorably, a series of witches including Witch Hazel for Chuck Jones. She appeared on the Smurfs, George of the Jungle, and How the Grinch Stole Christmas; she was the voice of the original "Chatty Cathy" doll, and is a voice on the Disney attraction "Pirates of the Caribbean".
Most recognizable, though, is her work for Jay Ward: she played nearly every female on The Rocky and Bullwinkle Show, including Natasha Fatale and Nell Fenwick, and (against sex) Rocket J. Squirrel (Rocky).
Chuck Jones said of her: "June Foray is not the female Mel Blanc. Mel Blanc was the male June Foray."