A friend persuaded Moore to drop out of high school at age 16 to become an actress. Her big break came playing the part of a coke addict in the Brat Pack film St. Elmo's Fire.
She has been married and divorced twice. Her first marriage was to musician Freddy Moore. She has three daughters by her marriage to actor Bruce Willis: Rumer Glen, Scout LaRue and Tallula Belle.
She appeared nude on the cover of Vanity Fair magazine in 1991 while seven-months pregnant, with enormous attendant publicity. At the height of her popularity she was spoofed with a cartoon version of herself (called "Dewmi Moore") in the popular video game series Leisure Suit Larry.
A recent film was G.I. Jane about a woman making a career within the Navy SEALs.
After a long break from her acting career Moore returned to the screen as a former member of Charlie's Angels in the film Charlie's Angels 2: Full Throttle. She is rumored to be in a romantic relationship with actor Ashton Kutcher, who is 15 years younger than her.