She has been married and divorced twice. Her first marriage was to musician Freddy Moore. She has three daughters by her marriage to actor Bruce Willis: Rumer Glen, Scout LaRue and Tallula Belle.
She appeared nude on the cover of Vanity Fair magazine in 1991 while seven-months pregnant, with enormous attendant publicity. At the height of her popularity she was spoofed with a cartoon version of herself (called "Dewmi Moore") in the popular video game series Leisure Suit Larry.
A recent film was G.I. Jane about a woman making a career within the Navy SEALs.
After a long break from her acting career Moore returned to the screen as a former member of Charlie's Angels in the film Charlie's Angels 2: Full Throttle. She is rumored to be in a romantic relationship with actor Ashton Kutcher, who is 15 years younger than her.