It is based in Erlanger, Kentucky, a city close to the Cincinnati-Northern Kentucky International Airport, which serves Cincinnati, Ohio. Comair operates under the name Delta Connection. It also operates some flights from William B. Hartsfield International Airport in Atlanta, Georgia. Comair once operated a lot of flights to Orlando International Airport in Orlando, Florida, but Chautauqua Airlines has taken the reins of the dominant RJ airline instead.
There is another Comair called BA Comair which resides in South Africa.