On May 27, 1995 he was paralyzed from the neck down after falling from his horse in a riding competition at Charlottesville, Virginia. He has largely retired from the production of films since his paralysis, instead devoting his time to rehabilitation therapy and, with his wife Dana, opening the Christopher and Dana Reeve Paralysis Resource Center, a facility in Short Hills, New Jersey devoted to teaching paralyzed people to live more independently.*
On February 25, 2003, he appeared as Dr. Swann in the TV series Smallville who provides young Clark Kent insightful clues as to his origins. The episode was warmly received by critics and the viewing public as a fitting connection from one generation's Superman to the next and it has been promised that Reeve's guest role will be recurring.