The design was adapted in the early 1960s for the RAF to become a general-purpose helicopter capable of troop-carrying, air ambulance and ground attack roles. It was first used by the RAF in 1962, and did not finally retire until 2003, being the main transport helicopter until the introduction of the Puma. The bright yellow RAF machines used for air-sea or mountain rescue duties became especially famous and saved many lives.
Wessex helicopters were also used by the Queen's Flight of the RAF to transport VIPs including members of the British Royal Family, from 1969 to 1998. Those Royal helicopters were designated HCC4 and were essentially similar to the HC2 but with an upgraded interior and additional navigation equipment. A later version used by Royal Navy commandos was the HC5.