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Tlaxcala is the name of a city and a state in Mexico. This article is about the city. For the state, see: Tlaxcala (state).

The city of Tlaxcala is the capital and chief center of population of the Mexican state of the same name. The city is located at 19.31° N, 98.24° W, and it reported a population of 73,184 in the 2000 census.

The city was founded in 1520 by Hernán Cortés.