Thyrotropin-releasing hormoneThyrotropin-releasing hormone
) is a tripeptide hormone
produced by the hypothalamus
and stimulating production of TSH
by the anterior lobe of the pituitary
It is passed from hypothalamus (eminentia mediana
) to the pituitary by
the means of the pituitary portal system.
The sequence of TRH was first determined and the hormone was synthetised by
Roger Guillemin and Andrew V. Schally in 1969.
The presence of TRH can also be detected in other parts of the brain, in the gastrointestinal system and pancreatic islets.
Medical preparations of TRH are used in diagnostic tests of thyroid disorders
and in acromegly.
Structure : (pyro)Glu-His-Pro-NH2
Molecular weight : 359,5 D