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SPI has multiple meanings. This is a disambiguation page.

SPI, short for Simulations Publications, Inc., was a publisher of board games in the 1970s and early 1980s. The company was founded in 1969 by James F. Dunnigan. When SPI went bankrupt in 1982, its assets were divided between game producers TSR and Avalon Hill.

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SPI stands for The Society of the Plastics Industry, a trade association for the plastics industry in the United States.

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In the open source movement, SPI stands for the Software in the Public Interest organization.

SPI, for Serial Peripheral Interface is a standard for serial communication between hardware peripherals, generally used for communications between microcontrollers and associated peripherals such as A/D converters, etc. SPI was invented by Motorola.