Lisazo as a youngster wanted to become a soccer player, and he played for various teams in Argentina as a kid. However, his calling as an actor would soon take him far away from Argentina, and in 1989, he had flown to Mexico, where he participated in his first telenovela: Amor de Nadie, alongside Lucia Mendez and Fernando Allende.
Lisazo went on to become a super-star actor in Mexico, becoming the main star in many soap operas, including the ones he made with Thalia and Gabriela Spanic. He also became a sex symbol in Mexico, and made a low budget film in Hollywood.
In 2002, Lisazo had to return to Argentina briefly, as his mother recuperated from an illness.
In 2003, Lisazo, generally considered by fans to be a good autograph signer, went on tour with del Castillo internationally, as their play was scheduled to be taken to the United States and other countries.