In 179 BC Philip V of Macedon died. In the previous year Philip had his pro-Roman son Demetrius executed. Perseus had been jealous of Demetrius' success as ambassador to Rome and had convinced their father to have him poisoned as a potential usurper. The Romans favoured Demetrius, and Perseus' role in killing Demetrius did not endear him to Rome when he took the throne.
One of his first acts on becoming king was to renew the treaty with Rome. Yet, Perseus' other actions troubled Rome. His interference in the affairs of his neighbours, his armed visit to Delphi, his avoidance of the Roman ambassadors to Macedonia, and his dynastic marriages all gave Rome cause for concern. Soon Rome and and Perseus were at war, which ended with Perseus' surrender to Paullus after the Battle of Pydna, and his eventual imprisonment in Rome. The Antigonid kingdom was dissolved, and replaced with three republics. In time these were also dissolved, and Macedon became a Roman province.