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Molise is a region of south central Italy,the second smallest of the regions. It was formerly (until 1963) part of the region of "Abruzzi e Molise" (with Abruzzo) and now a separate entity. It borders Abruzzo to the north-west, Lazio to the west, Campania to the south, Puglia to the south-east and the Adriatic Sea to the north-east.

The region covers 4,438 km² and has a population of about 330,000.

The regional capital is Campobasso. The region is divided into two provinces: Campobasso and Isernia.