The river's flow is heavily modified by the presence of two major dams, the Dartmouth Dam and the Hume Dam. Upstream of the Dartmouth Dam, the river flows swiftly through near-pristine forest. Below the dam, it travels more sedately through flatter, cleared farming country (some of which is now irrigated using its water, though most continues downstream to meet the needs of irrigators there).
The junction with the Murray is now submerged beneath the waters of Lake Hume for a large part of the time.
The river valley used to flood on a nearly annual basis, but the completion of Dartmouth Dam in the 1970's largely eliminated the floods.
The Mitta Valley contains four small towns: