The other main characters in the show were Wilbur's tolerant wife Carol (Connie Hines) and their neighbours the Addisons (Larry Keating and Edna Skinner) until 1963 and then the Kirkwoods (Leon Ames and Florence MacMichael). Mister Ed was voiced by Allan Lane (speech) and Sheldon Allman (singing).
The unaired pilot was called The Wonderful World of Wilbur Pope; reworked, it was first broadcast in January 1961 as a syndicated program before being acquired by CBS and aired by that network beginning in October. The 143rd and last episode was shown on September 4, 1966.
Mister Ed was portrayed by Bamboo Harvester, who was born in California in 1949 and died in 1970. He was trained for the show by Les Hilton, although some of the trickier stunts were apparently performed by a zebra. Another horse that had played Mister Ed in some publicity work died in 1979.
Compare to Francis the Talking Mule (1949-1956).