She was born in New Kent Co., Virginia, the daughter of John Dandridge and his wife Frances Jones.
Her first marriage was to Daniel Parke Custis, with whom she had four children, two of whom survived to adulthood, John Parke Custis (1754-1781) and Martha "Patsy" Custis.
She married George Washington on January 6, 1759, two years after the death of her first husband. Content to live a private life on Washington's Mount Vernon estate, she nevertheless followed him to the battlefield. She opposed his election as president and refused to attend his inauguration, but fulfilled her duties as the official state hostess graciously.
Martha and George Washington had no children together, but they raised Martha's grandson, George Washington Parke Custis (April 30, 1781 - October 10, 1857) after his father, John Parke Custis, was killed (while serving as an aide to Washington) during the siege of Yorktown in 1781.
Martha Washington died at Mount Vernon, Fairfax Co., Virginia, and was buried on May 22, 1802 at Mount Vernon. Her remains were moved in 1831 from their original burial site a few hundred feet to a brick tomb that overlooks the Potomac.