Mardy met her husband Olaus Murie in 1924. They took a honeymoon on a dogsled trip on Alaska's Koyukuk River. This area was later incorporated into the Arctic National Wildife Refuge.
Due to the efforts of the Muries (as leaders of the Wilderness Society), the US Government protected the Arctic National Wildlife Refuge in 1960. Mardy Murie also hatched the idea of the Wilderness Act, which was passed by the United States Congress in 1964. The Wilderness Act protected millions of acres of wilderness across the country.
Mardy Murie was also an author, who wrote about her Alaska and Wyoming adventures in books such as Two in the Far North and Wapiti Wilderness.
Mardy Murie passed away in her log cabin on October 19, 2003.