Majel Barrett played several onscreen roles in the various incarnations of Star Trek, the popular science fiction TV series. She first appeared in Star Trek's initial pilot episode "The Cage" as the USS Enterprise's unnamed First Officer. However, the network would not allow Roddenberry to have a woman in such a high position of authority, and subsequently her role was changed to that of Nurse Christine Chapel, and two decades later she was cast as the outrageously determined and iconoclastic Betazoid Ambassador Lwaxana Troi in Star Trek: The Next Generation, who also appeared in some episodes of Star Trek: Deep Space Nine. She also provided the "voice of the computer" for all four Star Trek series and their associated movies.
She also played the character Dr. Julianne Belman in Earth: Final Conflict, which was also created by Gene Roddenberry. She made a guest appearance in a Babylon 5 episode, as the widow of the Centauri emperor.
She was born as Majel Lee Hudec in Columbus, Ohio.