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MacLisp is a dialect of the Lisp programming language. It originated at MIT's Project MAC in the late 1960s and based on Lisp 1.5. MacLisp initially ran on DEC PDP-10 computers, was used to implement the Macsyma symbolic algebra program, and was in widespread use in the artificial intelligence research community through the early 1980s.

Lisp Machine Lisp is a direct descendant of MacLisp.