Born to Zeb Rudolph, a leading citizen of Hiram, Ohio, and devout member of the Disciples of Christ, she first met "Jim" Garfield when both attended a nearby school, and they renewed their friendship in 1851 as students at the Western Reserve Eclectic Institute, founded by the Disciples. But "Crete" did not attract his special attention until December 1853, when he began a rather cautious courtship, and they did not marry until November 1858, when he was well launched on his career as a teacher. His service in the Union Army from 1861 to 1863 kept them apart; their first child, a daughter, died in 1863. But after his first winter in Washington as a freshman Representative, the family remained together. With a home in the capital as well as one in Ohio they enjoyed a happy domestic life. A two-year-old son died in 1876, but five children grew up healthy and promising.
In Washington, DC they shared intellectual interests with congenial friends; she went with him to meetings of a locally celebrated literary society. They read together, made social calls together, dined with each other and traveled in company until by 1880 they were as nearly inseparable as his career permitted.
Garfield's election to the Presidency brought a cheerful family to the White House in 1881. Though Mrs. Garfield was not particularly interested in a First Lady's social duties, she was deeply conscientious and her genuine hospitality made her dinners and twice-weekly receptions enjoyable. At the age of 49 she was still a slender, graceful little woman with clear dark eyes, her brown hair beginning to show traces of silver.
In May she fell gravely ill, apparently from malaria and nervous exhaustion. She was still a convalescent, at a seaside resort in New Jersey, when he was shot by a demented assassin on July 2. She returned to Washington by special train--"frail, fatigued, desperate," reported an eyewitness at the White House, "but firm and quiet and full of purpose to save." During the three months her husband fought for his life, her grief and devotion won the respect and sympathy of the country. In September, after his death, the bereaved family went home to their farm in Ohio. For another 36 years she led a strictly private but busy and comfortable life, active in preserving the records of her husband's career. She died on March 14, 1918.