The legion main theatre of operations was the Roman province of Noricum, in the south margin of the Danube, where Germanic incursions were frequent. In 180 AD II Italica was stationed in Lauriacum, modern Lorch.
In 193 AD, II Italica marched into Rome with Septimius Severus, then fighting for power. The new emperor awarded them the title of Fidelis (loyal) to acknowledge the support. Later Septimius Severus would use II Italica against the rebellions of Pescinnius Niger and Clodius Albinus, and in his Parthian campaigns.
In the 3rd century, support of the legions was a crucial demand for candidates to the throne. Well aware of this fact, Gallienus granted II Italica the cognomina of VII Pia VII Fidelis (seven times faithful, seven times loyal) to secure their continuing support.