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Gnathostomata is the group of vertebrates with jaws.

The group is traditionally a superclass, including the familiar classes of fish, birds, and so forth, and a sister group of the jawless vertebrates Agnatha. However, recent genetic studies are causing a reassessment of Gnathostomata as a grouping.

Other distinguishing characteristics of living gnathostomates are the myelin sheathes of neurons, and an adaptive immune system.

The traditional classes of Gnathostomata include:

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