Giorgione came from the small town of Castelfranco Veneto, outside of Venice. His name is sometimes spelled Zorzo. The variant 'Giorgione' or 'Zorzon' means 'tall George'.
While still in Castelfranco he painted the Castelfranco Madonna, a fairly conventional image of the Madonna enthroned, with saints on either side. However, it marks a departure in Venetian art, with its curiously introverted saints and its delicate color modulations. This is painted with the tiny disconnected spots of color that Giorgione brought into oil painting, derived from manuscript illumination techniques. These gave Giorgione's works the 'magical' glow of light for which they were famous.
However it is works such as the Three Philosophers and The Tempest that are most famous. The meaning of these paintings is mysterious, though art historians have attempted to ascribe conventional subjects to them, they remain strange. The first depicts three figures near a dark empty cave. There seem to be suggestions of Plato's cave and of the three Magi, but it remains unclear. The same is true of The Tempest in which a soldier on one side of a stream and a breast-feeding woman on the other side seem to be awaiting a storm.
His life was described in Giorgio Vasari's Vite.