With her new friends, she soon was associating with the artistic crowd in Montmartre and Montparnasse including the sculptor Emmanuel Centore who would eventually marry her sister Jeanne. It was in the Montparnasse atelier of one of her painter friends where the initial idea for Les Six began. The publication of Jean Cocteau's manifest Le Coq et L'Harlequin resulted in Henri Collet's media articles that lead to instant fame for the group. As the only female, she brought a uniquely fresh and feminine quality to the group’s compositions. Today, she is one of the most recorded.
The other members of "Les Six" were:
On her own, Tailleferre wrote a series of short works for the piano during the 1920s - 1930s as well as several film scores. At the outbreak of World War II, she was forced to leave her home near Nice. Escaping across Spain to Portugal, she found passage on a boat that brought her to America where she lived the war years in Philadelphia, Pennsylvania. After the war, in 1946, she returned to her home in France where she composed orchestral and chamber music, plus numerous other works including four full-length ballet scores, four full-length operas, as well as many shorter operas and two musical comedies. The majority of this music was not published until after her death.
During the 1960s, she composed a large number of scores for films and television and in 1976, she accepted the post of accompanist for a children's music and movement class at the École Alsacienne, a private school in Paris.