The municipality also comprises the following towns, villages and townships: Boekelo, Glanerbrug, Lonneker, Usselo.
The city is a former centre of textile production. The Universiteit Twente, with mostly technical studies, is located in Enschede.
Enschede is a terminal station of the NS railway network on the west, and of the DB Regionalbahn Westfalen railway network (part of the German Deutsche Bahn) on the east. Two more stations of the latter are in the Netherlands: "Enschede De Eschmarke" and "Glanerbrug". The nearest main town is Gronau, Germany.