Hall of Famers George Blanda and Billy Cannon benefited from his blocking as the Oilers won the first two AFL Championships. Talamini made first-team All-AFL in 1962 and was a regular at American Football League All-Star games, selected to six straight, through 1967. He anchored an offensive line that gave Blanda time to set passing records that would last for decades and opened holes for the likes of Cannon, Charlie Tolar, Sid Blanks and Hoyle Granger to run through. Talamini, Don Floyd and Jim Norton were the last of the original Oilers.
After two AFL crowns and three Eastern Division titles, Talamini watched the club rebuild and win the division again in 1967. The Oilers fell one game short in 1967, but Talamini got to realize his dream the following year when he was released and picked up by the New York Jets. Opening holes for Matt Snell and blocking defenders away from Joe Namath, Bob played a vital role in the shocker that changed pro football forever, stuffing the Colts in Super Bowl III. Talamini was selected to the All-Time All-AFL second team, and is a member of the American Football League Hall of Fame