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In modern medicine, apoplexy is used synonymously with stroke, although strictly speaking it applies only in cases of intracerebral bleeding.

The term is also used to describe severe bleeding into other organs, although in such usage, it is coupled with an adjective describing the site of the bleeding. For example, bleeding within the kidneys can be called renal apoplexy, or bleeding within the pituitary gland can be called pituitary apoplexy.

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