It has a provincially protected Temple of the God of Medicine (藥王廟) established around 100.
In premodern China, Anguo was Qizhou (祁州). In 1991, Anguo was changed from county into a city. The city governs 20 town-level entities in 486 kmē, of which the centrally placed Yaocheng (药城) is the municipal seat. The Chinese playwright Guan Hanqing was born here.