In the New Testament this word always implies execration. In some cases an individual denounces an anathema on himself unless certain conditions are fulfilled (Acts 23:12, 14, 21). "To call Jesus accursed" [anathema] (1 Cor. 12:3) is to pronounce him execrated or accursed. If any one preached another gospel, the apostle says, "let him be accursed" (Gal. 1:8, 9); i.e., let his conduct in so doing be accounted accursed.
In Rom. 9:3, the expression "accursed" (anathema) from Christ, i.e., excluded from fellowship or alliance with Christ, has occasioned much difficulty. The apostle here does not speak of his wish as a possible thing. It is simply a vehement expression of feeling, showing how strong was his desire for the salvation of his people.
The anathema in 1 Cor. 16:22 denotes simply that they who love not the Lord are rightly objects of loathing and execration to all holy beings; they are guilty of a crime that merits the severest condemnation; they are exposed to the just sentence of "everlasting destruction from the presence of the Lord."
This article contains material from Easton's Bible Dictionary (1897).