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Amide hydrolysis

Amide hydrolysis involves the C-N bond being broken in reaction with water (hydrolysis). The reaction is catalysed by either acid or alkali.


The amide is heated under reflux with moderately concentrated acqueous acid or alkali. If an acid is used, the product contains Ammonia ions. If a alkali is used, the carboxylic acid loses an H+ ion and the product contains carboxylate ions.