On May 29, 1868 he was born at Dolmabahçe (dolmabahche) Palace of Istanbul (form. Constantinople) to then Sultan Abd-ul-Aziz. He was educated privately. On July 4, 1918 his first cousin Mehmed VI became Sultan and Abdul Mejid was named Crown Prince. Following the deposition of his cousin on November 1, 1922 the Sultanate was abolished. But on November 19, 1922, the Crown Prince was elected Caliph by the Turkish National Assembly at Ankara. He established himself in Istanbul, on 24th November 24, 1922. On March 3, 1924 he was deposed and expelled from the shores of Turkey with the rest of his family.
He was given the title of General of Ottoman Army and served as Chairman of the Ottoman Artist's Society. A painter himself, his portraits of Ludwig van Beethoven, Johann Wolfgang von Goethe and Selim I were displayed at the Vienna Exhibition of 1918.
On December 23, 1896 he was first married at the Ortaköy Palace to H.H. Shahsuvar Bash Kadin Effendi (Istanbul (form. Constantinople) May 2, 1881 - Paris,France 1945). They had a son:
On March 21, 1921 he was married fourthly at Çamlica (chamlidcha) Palace to Bihruz 4th Kadin Effendi (born at Izmir, May 24, 1903).
On August 23, 1944 Abdul Mejid II died at his house in the Boulevard Suchet, Paris XVIe, France. He was buried at Haram-i-Sharif, Medina, Saudi Arabia.