Decades: 500s BC 490s BC 480s BC 470s BC 460s BC - **450s BC** - 440s BC 430s BC 420s BC 410s BC 400s BC

Years: 465 BC 464 BC 463 BC 462 BC 461 BC - **460 BC** - 459 BC 458 BC 457 BC 456 BC 455 BC

- Egypt revolts against Persia, starting a six year war. An Athenian force sent to attack Cyprus is diverted to support this revolt.

- Hippocrates of Cos, Greek physician
- Thucydides, Greek historian